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M K Danks Selected Research

Carboxylesterase (Hydrolase S)

5/2008Stem and progenitor cell-mediated tumor selective gene therapy.
7/2001A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11.
7/2001Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase.
5/2000Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11.

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M K Danks Research Topics

Disease

7Neoplasms (Cancer)
05/2008 - 05/2000
4Neuroblastoma
07/2001 - 05/2000
1Carcinoma (Carcinomatosis)
04/2001
1Rhabdomyosarcoma
05/2000

Drug/Important Bio-Agent (IBA)

5EnzymesIBA
05/2008 - 05/2000
4ProdrugsIBA
05/2008 - 05/2000
4Carboxylesterase (Hydrolase S)IBA
05/2008 - 05/2000
4Irinotecan (Camptosar)FDA LinkGeneric
03/2008 - 05/2000
2Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA
04/2001 - 05/2000
2Transcription Factors (Transcription Factor)IBA
04/2001 - 05/2000
2Proteins (Proteins, Gene)FDA Link
04/2001 - 05/2000
1Metalloproteases (Metalloproteinases)IBA
05/2008
1InterleukinsIBA
05/2008
1LigandsIBA
05/2008
1Thymidine KinaseIBA
05/2008
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2008
1Interferon-betaIBA
05/2008
1Cytosine DeaminaseIBA
05/2008
1SynaptophysinIBA
07/2001
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
07/2001
1RNA (Ribonucleic Acid)IBA
07/2001
1NeomycinFDA LinkGeneric
04/2001
1Chloramphenicol O-Acetyltransferase (Chloramphenicol Acetyltransferase)IBA
05/2000

Therapy/Procedure

4Therapeutics
05/2008 - 03/2001
1Drug Therapy (Chemotherapy)
08/2000